LATEST NEWS
- Our book chapter “Automated Analysis of Phase-Contrast Optical Microscopy Time-Lapse Images: Application to Wound Healing and Cell Motility Assays of Breast Cancer” is published in Diagnostic Biomedical Signal and Image Processing Applications.
- Prof. Unay gave an invited talk at the 16th Multinational Congress on Microscopy (September 5th, 2022 at the session IM1: Multi-dimensional Image Processing).
- We organized a special session on Microscopy Image Analysis at the TıpTekno'22 conference.
- Mahmut Uçar presented our work "Detection and restoration pipeline for phase contrast microscopy time series images" at the Microscopy Image Analysis special session at TıpTekno'22 conference.

Title: Development of Image Processing and Machine Learning based Tools for Analysis of Phase-Contrast Optical Microscopy Time Series Images

Funding: TÜBİTAK ARDEB 1001.

Duration: 1.7.2020-1.7.2023

Partners: İzmir Democracy University (IDU), İstanbul Technical University (ITU), İzmir Institute of Technology (IYTE)

Description:  In this project image processing and machine learning-based approaches will be developed for morphological and movement analyses of breast cancer cell lines from phase-contrast optical microscopy time-series images. Towards this aim, our focus will be on the biological problems of cell motility (the case where a low number of isolated cells independently translocate) and wound healing (the case where cells move as tightly or loosely associated cohesive groups).

The team:

  • Researchers: Devrim Ünay – PI (IDU), Behçet Uğur Töreyin (ITU), Devrim Pesen Okvur (IYTE), Özden Yalçın Özuysal (IYTE)
  • Scholarship holders: Yusuf Sait Erdem (MS student, IDU), Mahmut Uçar (MS student, IDU), Kenan Morani (PhD student, IDU), Berkay Mayalı (Undergrad student, IDU)
  • External researchers: Sevgi Önal (University of Canterbury), Leonardo O. Iheme (Mayo Clinic)
  • Alumni: Aydın Ayanzadeh (Ph.D. student, Univ. Maryland Baltimore), Özge Nur Belli (Tübitak Star grantee, IYTE), Muhammed Balıkçi (Undergrad student, IYTE), Mehmet Kaan Erol (Tübitak Star grantee, Marmara U.)

Publications:

Exemplary deformations observed in PCM videos

Monotonic intensity variation
High intensity variation
Geometric shift
Blank frame
Lens distortion
Background variation